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Social Cognitive and Affective Neuroscience Advance Access published online on July 21, 2007
Social Cognitive and Affective Neuroscience, doi:10.1093/scan/nsm029
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© The Author (2007). Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org

Amygdala–frontal connectivity during emotion regulation

Sarah J. Banks1, Kamryn T. Eddy1, Mike Angstadt1, Pradeep J. Nathan1,2 and K. Luan Phan1,2,3

1Brain Imaging & Emotions Laboratory (BIEL), Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA, 2Behavioural Neuroscience Laboratory (BNL), Department of Physiology, Monash University, Victoria, VIC 3800, Australia, and 3Center for Cognitive Social Neuroscience, University of Chicago, Chicago, IL, 60637, USA

Successful control of affect partly depends on the capacity to modulate negative emotional responses through the use of cognitive strategies (i.e., reappraisal). Recent studies suggest the involvement of frontal cortical regions in the modulation of amygdala reactivity and the mediation of effective emotion regulation. However, within-subject inter-regional connectivity between amygdala and prefrontal cortex in the context of affect regulation is unknown. Here, using psychophysiological interaction analyses of functional magnetic resonance imaging data, we show that activity in specific areas of the frontal cortex (dorsolateral, dorsal medial, anterior cingulate, orbital) covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task. Moreover, strength of amygdala coupling with orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal. These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.

Keywords: emotion; fMRI; functional connectivity; psychophysiological interaction; amygdala; prefrontal; regulation; reappraisal

Correspondence should be addressed to Dr K. Luan Phan, Brain Imaging & Emotions Laboratory, Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue (MC 3077), Chicago, IL 60637, USA. E-mail: luan{at}uchicago.edu

Received April 16, 2007. Accepted June 23, 2007.


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